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July 2002

Case submitted by Stephen M. Schleicher, MD, and Lawrence A. Schiffman, DO

July 2002 Diagnosis at a Glance

CASE:

The patient is a 22-year-old female college student who has had painful lesions on both legs for approximately six weeks. She had a similar condition two years ago that resolved spontaneously. Otherwise in good health, she takes birth control pills but no other medications regularly. She denies malaise, fever, and joint pain. Examination of both lower legs reveals scattered dusk-colored to violaceous subcutaneous nodules that are tender to light palpation. No lesions are noted elsewhere.

What is your diagnosis?
 
July 2002 Diagnosis at a Glance
Erythema nodosum, characterized by tender lesions arising on the lower extremities, is more common in women. Fever and arthralgias may precede the eruption of multiple discrete, indurated, hyperpigmented nodules, defined histologically as panniculitis. The etiology may be infectious—beta-hemolytic streptococci are a common cause—or drug-related, including oral contraceptives. The condition may also accompany sarcoid and inflammatory bowel disease. The diagnostic workup therefore should include a detailed history as well as throat culture and radiologic examination of the lungs.


Dr. Schleicher is director of the DermDx Centers for Dermatology of Northeastern Pennsylvania and a clinical instructor of dermatology at Graduate Hospital's City Line Campus in Philadelphia, Kings College in Wilkes-Barre, and Beaver College in Glenside, Pennsylvania. He is also a member of the EMERGENCY MEDICINE editorial board. Dr. Schiffman is a fellow at the DermDx Centers for Dermatology.

 



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